ea0031s12.1 | Thymic function and autoimmune endocrine disease | SFEBES2013
Anderson Graham
A key role of the thymic medulla is to negatively select CD4+ and CD8+ thymocytes expressing potentially autoreactive αβT-cell receptors (αβTCR), a process important for T-cell tolerance induction. It is known that tolerance induction in the thymus involves multiple processes, and the thymus medulla is also known to contribute through guiding the generation and selection of natural FoxP3+ regulatory T-cells (nT-Reg). Of the ...